DOI: 10.36347/sajp.2024.v13i05.003

Pages: 145-152

The skin's barrier function typically places restrictions on the transdermal administration of medications. One of the most contentious techniques for transdermal distribution of active ingredients is vesicular systems. After elastic vesicles such as transferosomes, ethosomes, cubosomes, phytosomes, etc. were discovered, there was a renewed interest in developing transdermal delivery systems. In order to provide active compounds transdermally, this paper describes the composition, penetration mechanisms, production processes, and characterization techniques of transferosomes. A medication must cross one or more biological membranes or barriers at different sites in order to be absorbed, distributed into organs and tissues, and removed from the body. Substance transport refers to the passage of a substance through a membrane in this manner. The medications must get through the membranous barrier in order to be absorbed by the body. In an effort to reduce the amount of medicine in the remaining tissues and concentrate the drug in the targeted tissues, several delivery systems were devised. As a result, the medication has no effect on the tissues nearby. Furthermore, medication loss does not occur. Furthermore, the localization of the drug prevents drug loss, resulting in the medication's optimum efficacy. As such, there is a lot of interest in phospholipid-based carrier systems nowadays.