DOI: 10.36347/sjams.2024.v12i05.020

Pages: 634-640

Background: Diabetic nephropathy, the most common complications of diabetes mellitus, is the chronic loss of kidney function occurring in diabetic patients. Usually, diabetic nephropathy manifestation grows after 10 years duration in case of type 1 diabetes but in case of type 2, it may manifest even at the time of diagnosis. Microalbuminuria is the earliest manifestation of diabetic nephropathy. Microalbuminuria is the persistent elevation of albumin in urine between 30-300 mg/day, below 30 mg/day is normoalbuminuric and above 300 mg/day is macroalbuminuria. So, screening for microalbuminuria should be initiated from the time of diagnosis of T2DM which is sometimes avoided by the physician, overlooked by patient and both. Moreover, urine for albumin may show even normal when nephropathy has already been started. For this, some other early detective markers need much more attention. Serum cystatin C can be that predictive marker for early recognition of diabetic nephropathy in case of T2DM patients. Serum cystatin C reflects increased urinary albumin concentration and reduced glomerular filtration rate both at the very early stages when microalbuminuria not even developed and GFR is not reduced. Objective: To evaluate serum cystatin C level as an early predictive marker of nephropathy in type 2 diabetic patients. Materials and Methods: This was a cross sectional study done in the Department of Biochemistry and Molecular Biology, BSMMU. Subjects (total one hundred sixty-six in number) from Endocrinology & Metabolism OPD of BSMMU who matched the inclusion and exclusion criterias were enrolled in the study by non-probability purposive sampling technique and an informed written consent was taken from all who agreed to participate in the study. Data were collected after IRB approval using a data collection sheet in Bengali. This sheet contained information about socio-demographic characteristics, information about any previous or co-existing disease, anthropometric .....