DOI: 10.36347/sjmcr.2024.v12i05.097

Pages: 946-950

Introduction: Follicular dendritic cell tumors (CDF tumors) are rare, it is an uncommon neoplasm derived from non-lymphoid accessory cells of peripheral lymphoid tissue. FDCS is grouped with histiocytic neoplasms and dendritic cell neoplasms in the World Health Organization tumor classification. Observation: We report the case of a 37-year-old patient followed for dendritic follicular cell sarcoma of the epithelioid type of the left amygdala. He underwent surgical removal of the left tonsil, followed by chemotherapy such as Cyclophosmide, Doxorubicin, Vincristine, and Prednisolone (CHOP) and radiation therapy at the 60 Gy dose. Discussion: FDC sarcoma is an uncommon neoplasm of antigen-presenting cells of B-cell follicles of lymphoid organs. According to the World Health Organization’s classification of hematopoietic and lymphoid tumors, FDCS belong to histiocytic and dendritic cell neoplasms. The appearance of follicular dendritic cell sarcoma of the amygdala, in an extra lymph node site, as occurred in our patient has rarely been observed. Histologically, FDCT cells appear as strands with a storiform, verticillated, and prominent pattern. On the immunohistochemistry level, we note the positivity of antibodies CD21, CD23 or CD35. Treatment is based on broad surgical excision followed by adjuvant chemotherapy and radiotherapy. However, these complementary treatments have not contributed to long-term survival. The evolution is marked by local or metastatic recurrences. Conclusion: Although rare, dendritic follicular cell sarcomas of epithelial type may have as a starting point the head and neck region, lymphoid, and extra ganglion sites.