DOI: 10.36347/sjams.2020.v08i08.035

Pages: 1965-1968

Total Knee Arthroplasty is associated with significant amount of blood loss and may increase the need of blood transfusions. Various blood loss management strategies have been used in the past and Tranexamic Acid is one such commonly used method due to ease of administration and low cost. The use of TXA in primary TKA is associated with reduced transfusion rates, early discharge to home, and reduced economic burden on the patient. Tranexamic Acid can be administered through various routes that include oral, intravenous and intra-articular. However there is no clear consensus on the ideal dosage and route of administration. This study was conducted to compare the effect of intra-venous Tranexamic acid with intra-articular Tranexamic acid on post-operative blood loss after unilateral primary total knee arthroplasty (TKA).A total of 58 patients of either gender planned to undergo unilateral total knee replacement (TKR) were enrolled in each of the two groups. In group A (Intra venous Tranexamic acid group) 2 gram intra venous Tranexamic acid was injected. In Group B (Intra-articular Tranexamic acid group), patients were given 2 gram intra-articular Tranexamic acid. All patients were followed up to 72 hours after completion of surgery. Blood collection in negative suction drain was noted after every 24 hours. The mean drainage total blood loss during 72 hours was 637.32±103.53 ml in Group A (intravenous Tranexamic acid)) and 546.35±70.73ml in Group B (Intra-articular Tranexamic acid). The difference was significant in Group A and Group B.Patients who received intra-articular TXA had a lesser drain output (p<0.05) as compared to intravenous administration of Tranexamic Acid. Intra-articular administration of TXA is more effective in reducing postoperative blood loss after primary TKA as compared to intravenous route.