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SAS Journal of Surgery | Volume-10 | Issue-06
Role of Beta Catenin, GAB1, YAP1 and P53 Antibodies in the Molecular Classification of Medulloblastoma: Analysis of a Series of 68 Cases
H. EL Khadraoui, C. Benallal, M. Krifech, S. Benali, M. Oi, H. Rais
Published: June 21, 2024 | 48 83
DOI: 10.36347/sasjs.2024.v10i06.015
Pages: 709-711
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Abstract
Medulloblastoma can occur at any age, but most commonly occurs during childhood. It is the second most common CNS malignancy in children. It’s must now be classified according to a combination of molecular and histopathological features. There are 4 genetically defined groups and 4 histologically defined groups: Genetically defined: WNT activated, SHH activated (either TP53 mutant or TP53 wild type), non-WNT / non-SHH, Histologically defined: classic, desmoplastic / nodular, medulloblastoma with extensive nodularity and large cell / anaplastic medulloblastoma. We report a retrospective study, spread over 68 months covering 21 cases Colligated at the CHU Mohammed VI of Marrakech between January 2018 and August 2023.