DOI: 10.36347/sjams.2024.v12i06.015

Pages: 803-809

Background: Duodenal ulcer perforation is a common surgical problem, it usually causes peritonitis. Postoperative minor and major complications are common in patients with peritonitis. Intraoperative peritoneal lavage is an important step of operative management and choice of fluid for peritoneal lavage can affect the outcome. Objectives: To compare the immediate post-operative outcome of povidone-iodine based normal saline lavage and normal saline lavage in duodenal ulcer perforation. Methods: This Quasi experimental study intended to compare the immediate post-operative outcomes between povidone-iodine based normal saline versus normal saline lavage in duodenal ulcer perforation. A total of 100 cases of duodenal ulcer perforation underwent laparotomy in Dhaka Medical College Hospital from January 2021 to December 2022, included in this study according to the inclusion and exclusion criteria. Cases were non-randomly allocated to group A (peritoneal lavage with povidone-iodine based normal saline) and group B (peritoneal lavage with normal saline). Each group consisted of 50 patients. The outcome variables were sepsis, wound infection, intra-abdominal abscess, burst abdomen and hospital stay. Data were analyzed and compared by statistical tests. Results: In povidone iodine based normal saline group, there was significant reduction in postoperative wound infection (p=0.042), sepsis (p=0.0414) and hospital stay (p=0.0173). No significant differences were found regarding age (p=0.3466), intra-abdominal abscess (p=0.646) and burst abdomen (p=0.522) between two groups. Conclusion: Povidone-iodine based normal saline lavage was better than only normal saline lavage in duodenal ulcer perforation in terms of wound infection, sepsis and hospital stay.