DOI: 10.36347/sjams.2024.v12i06.016

Pages: 810-816

Background: Thrombocytopenia is the most common cause of mucocutaneous bleeding in children due to various aetiologies. Hypo production or hyper destruction is the main aetiopathology of thrombocytopenia. Platelet indices might help to identify the underlying aetiopathology of thrombocytopenia. Objectives: To evaluate platelet indices to identify hypo productive and hyper destructive thrombocytopenia. Methods: This cross-sectional analytical study was conducted at Dhaka Shishu Hospital from July 2018 to June 2020. Cases were included in the study based on inclusion and exclusion criteria. A complete blood count was performed with a haematology analyzer, and other clinically indicated investigations were conducted to find the etiology of thrombocytopenia. A peripheral blood smear was also examined to estimate platelet count and to rule out pseudo thrombocytopenia and fragmented cells. 138 thrombocytopenic cases were studied divided into hypo-productive (n=60) and hyper-destructive (n=78) groups. Then, the values of the platelet indices of each group were compared with those of the comparison group. Data was analyzed by SPSS version 22. Results: In hypo productive thrombocytopenia, MPV was 7.68±0.67 fl, and PDW was 10.52±2.25 fl. In hyperdestructive thrombocytopenia, MPV was 10.09±0.85 fl, and PDW was 17.86±6.55 fl. There was a statistically significant (P <0.05) difference of platelet indices compared to normal values in the hypo productive and hyper destructive group. In hypo productive thrombocytopenia, MPV at 7.75 fl showed 76.1% sensitivity and 46.7% specificity, and PDW at 11.55 fl showed 78.3% sensitivity and 65.0% specificity. In hyper-destructive thrombocytopenia, MPV at 9.05 fl showed 89.7% sensitivity and 80.4% specificity, and PDW at 14.3 fl showed 74.4% sensitivity and 71.7% specificity. Conclusion: In hypo productive thrombocytopenia, platelet indices were significantly lower than normal values, and MPV at 7.75 (fl) showed 76.1% sensitivity and 46.7% ...