DOI: 10.36347/sjams.2020.v08i09.019

Pages: 2073-2079

Objective: In this study our main goal is to comparison of the effectiveness of metoclopramide combined with dexamethasone and granisetron alone in preventing post-operative nausea and vomiting in high risk patients undergoing laparoscopic cholecystectomy. Method: It is a cross sectional observational study on 120 patients who underwent laparoscopic cholecystectomy. The study period was July, 2017 to June, 2018. The study was conducted in the department of Anesthesia, Analgesia and Intensive care medicine of BSMMU. All the patients were chosen by purposive sampling. The study population was divided into two groups by simple lottery method. Group A patients got Granisetron (1mg iv single dose) and Group B patients got Metoclopramide and Dexamethason (Inj. Metoclopramide (10mg) and Inj. Dexamethasone (8mg)) just before induction. The observations were plotted into tabular and figure form. The categorical variable was analyzed by chi square test and the quantitative variables were analyzed by unpaired student’s t test. Results: The mean age of Group A and B patients were 33.73±6.97 and 34.62±7.16 years respectively. The sex ratio showed 21:39 and 15:45 in case of Male: Female respectively.out of 60 patients in each group PONV was reported in 20 (33.33%) and 16(26.67%) patients in Group A and Group B respectively. No PONV was reported in 40 (66.67%) and 44 (73.33%) patients in Group A and B respectively. 40(66.67%) and 44(73.33%) in Group A and B respectively showed no nausea and vomiting. 8(13.33%) and 7(11.67%) patients showed score 1 (nausea) in Group A and B respectively. On the contrary, 7(11.67%) and 5(8.33%) patients in Group-A and B respectively were categorized PONV score 2 (who experienced both nausea and vomiting. Only 5(8.33%) and 4(6.67%) patients experienced repeated vomiting ≥2 times who were categorized as PONV score 3.(p= 0.872). Among rescue antiemetic drug, analgesic drug use and postoperative hospital stay nothing but the hospital stay showed ......