DOI: 10.36347/sasjm.2024.v10i07.018

Pages: 677-682

Crohn's disease (CD) is a chronic inflammatory bowel disease (IBD) characterized by chronic inflammation of the gastrointestinal tract extending from the mouth to the anus. Vitamin D deficiency is common in this disease. This study aims to examine the correlation between vitamin D levels and the clinical and endoscopic activity of CD. Between July 2018 and July 2023, 267 patients were followed up for CD. Of these patients, 156 benefited from a Vitamin D assay, i.e. 58.42% of patients. The mean age was 40.8 +/- 13 years. The sex ratio was F/H = 1.6 (F=96, H=60). Vitamin D deficiency was found in 93 patients (59.61%). Our analysis reveals several key findings: An association between inadequate vitamin D levels and increased severity of CD. However, the exact nature of this relationship is complex and multifactorial. Patients with CD often have problems of intestinal malabsorption due to inflammation of the intestinal mucosa, which may contribute to vitamin D deficiency. Reduced sun exposure, common in CD patients, can also contribute to vitamin D deficiency. Regular monitoring of vitamin D levels and supplementation when necessary can play a crucial role in the overall management of CD. This study highlights the importance of continuing to explore the mechanisms underlying the relationship between vitamin D and CD, with a focus on the clinical implications for better patient management. In sum, our study contributes to our understanding of the influence of vitamin D on CD, while highlighting the importance of considering this vitamin in the assessment and management of patients with this complex disease.