DOI: https://doi.org/10.36347/sasjs.2024.v10i08.008

Pages: 942-946

Background: This prospective observational study aimed to compare the efficacy and safety of conventional-dose versus low-dose Bupivacaine combined with Fentanyl in patients undergoing open cholecystectomy under spinal anesthesia. Objectives: To compare the efficacy of conventional-dose versus low-dose Bupivacaine combined with Fentanyl in providing adequate anesthesia for open cholecystectomy under spinal anesthesia. Methods: This prospective observational study conducted at North Bengal Medical College Hospital between 2021 and 2023, the study included a sample size of 150 patients. Patients were divided into two groups: the conventional-dose group (Group A, n=75) received 15 mg of Bupivacaine with 25 µg of Fentanyl, and the low-dose group (Group B, n=75) received 7.5 mg of Bupivacaine with 25 µg of Fentanyl. Parameters such as hemodynamic stability, duration of analgesia, postoperative pain scores, and incidence of adverse effects were recorded and analyzed. Result: Group B demonstrated better hemodynamic stability with fewer episodes of hypotension and bradycardia compared to Group A. The duration of analgesia was slightly shorter in Group B, but postoperative pain scores were comparable between the two groups. Adverse effects, including nausea, vomiting, and pruritus, were less frequent in Group B. Conclusion: The study suggests that low-dose Bupivacaine combined with Fentanyl is a viable alternative to conventional-dose regimens for spinal anesthesia in open cholecystectomy, offering comparable analgesia with improved hemodynamic stability and fewer adverse effects. Further research is recommended to corroborate these findings and explore long-term outcomes.