DOI: https://doi.org/10.36347/sjams.2024.v12i08.019

Pages: 1028-1035

Background: Diabetes mellitus (DM) is the most significant public health challenges in both developed and developing countries. Diabetic nephropathy (DN) is one of the major causes of morbidity and mortality among patients with DM worldwide. Iron modify glucose metabolism and glucose metabolism impinges on iron. Objective: To evaluate serum iron profile in type 2 diabetic patients with or without diabetic nephropathy. Methods: This cross-sectional study was conducted at Department of Biochemistry and Molecular Biology, Bangladesh Institute of Research and Rehabilitation for Diabetes, Endocrine and Metabolic Disorder (BIRDEM), Dhaka, Bangladesh from January 2019 to December 2019. Total 150 participants were enrolled according to the selection criteria and were divided into three groups, 50 patients were with type 2 diabetes mellitus (T2DM), 50 patients were with DN and another 50 respondents were healthy controls. All relevant data were recorded and their serum iron profile was estimated accordingly. Data were analyzed and compared by statistical tests. Results: Male and female were 41.3% and 58.7% respectively and majority (31.3%) was in 51-60 years. The mean value of HbA1C of DN patients was significantly higher among groups (p<0.001). It was found that serum iron and serum ferritin were significantly (p<0.001) higher and total iron binding capacity (TIBC) was significantly (p<0.001) lower in T2DM and DN patients compare with healthy controls. The mean serum creatinine level was significantly (p<0.001) higher and mean value of estimated glomerular filtration rate (eGFR) was significantly (p<0.001) lower in DN patients. There were significant negative correlation of serum iron and significant positive correlation of TIBC with eGFR in patients with DN; but a negative correlation of serum ferritin with eGFR in patients with DN. Conclusion: It was observed that, serum iron, serum ferritin levels were significantly increased and TIBC was significantly decreased ........