DOI: 10.36347/sjavs.2018.v05i02.008

Pages: 98-103

Many plants have been used for years to treat various diseases. One of the plants used for this purpose is oregano. In this study, by adding different doses of oregano essential oil to lamb rations, histopathological and immunohistochemical changes in the liver were investigated. In the study, 3 groups (8 lambs in each group) were formed using 24 male lambs at the age of 3 months; Control group given basal ration, Oregano-1 given basal ration+200 mg/kg oregano essential oil and Oregano-2 given basal ration + 400 mg/kg oregano essential oil. In conclusion, it was determined that there were slight degenerative changes in hepatocytes in Oregano-2, in addition, heat shock protein 27 (HSP-27) release and 8-hydroxy-2-deoxyguanosine (8-OHdG) immunosuppressivity were higher in hepatocytes, vascular endothelial cells, and gland epithelial cells than in other groups.