DOI: https://doi.org/10.36347/sjams.2024.v12i08.022

Pages: 1049-1054

Background: Major electrolyte imbalance during various organ dysfunction is a condition that can be overcome. Unfortunately, some antihypertensive, such as ACE inhibitors and ARBs, can produce silent hyponatremia, which is exceedingly harmful to the human body. Aim of the study: The purpose of this study was to determine the frequency of hyponatremia in patients taking ACE inhibitor and ARB. Methods: From May 2019 to October 2019, this cross sectional observational study was conducted at Department of Medicine, Shaheed Ziaur Rahman Medical College Hospital, Bogura, Bangladesh. Purposive sampling was used to choose a sample of patients attending the Medicine department who were on ACE inhibitors and ARB medicines. Following that, they were evaluated using eligibility criteria, and 100 patients were chosen. All of the patients had been diagnosed with hypertension. Data on clinical biochemistry and surgical profile were collected. Data were analyzed using SPSS (version 23). Results: Among 50 patients in each group, the highest 19(38%) and 21(42%) belonged to ARB group and ACEi group respectively from age group (61-70 +). The male to female ratio in ARB and ACEi groups were 2.57:1 and 1.77:1 respectively. Among 50 patients in each group 4(8%) and 11(22%) patients in ARB and ACEI group respectively developed hyponatremia. The mean of total 15 hyponatremia patients was 128.73±2.17 mmol/L. Besides ARB group and ACEi group hyponatremia patients had mean serum sodium value like 130.31±1.79 mmol/L and 127.79±2.73 mmol/L respectively which shows statistically significant difference (P=<0.001). Conclusion: Hyponatremia was discovered in 31% of AECI and ARB patients. Though the amount is not excessive, it is disturbing. The incidence of hyponatremia among patients on these two medications varied statistically.