DOI: https://doi.org/10.36347/sjams.2024.v12i08.023

Pages: 1055-1059

Background: The kidneys are two vital excretory organs. It can be harmed by the toxic effects of chemicals, poisons, or the extended and uncontrolled use of medications. Cinnamon is used to flavor pastries and dishes. This plant is one of the oldest medicinal plants used in traditional medicine as a potent medication that may have nephroprotective properties. Aim of the study: The purpose of our study was to investigate the serum creatinine levels in Wister Albino male rats to examine the impact of cinnamon on gentamicin-induced nephrotoxicity. Methods: This experimental study was conducted in the department of Physiology, Sir Salimullah Medical College (SSMC), Dhaka from 1st January 2021 to 31st December 2021. A total number of thirty (30) apparently healthy Wister albino male rats, 90-120 days old, weighing between 150-200 gm were taken for the study. All acquired data was entered into a Microsoft Excel Work Sheet and analyzed using descriptive statistics in SPSS 22.0. Results: The mean (±SD) initial body weight of rats on day-1 were 177.10 ± 5.92, 183.80 ± 9.31 and 178.60 ± 8.19 gm, the final body weight on day- 29 were 208.40 ± 7.52, 207.0 ± 10.30 and 215.80 ± 9.26 gm. The percent (%) change of body weight from final to initial were 17.67 ± 0.98, 12.65 ± 1.23 and 20.85 ± 0.76 % and the kidney weight of rats were 0.86 ± 0.08, 1.25 ± 0.19 and 1.10 ± 0.18 gm in group A1, group A2 and group B respectively. the mean (±SD) kidney weight was significantly (p<0.001) higher in group A2 and group B (p< 0.01) in comparison to that of group A1. Whereas this levels were significantly (p<0.05) lower in group B in comparison to that of group A2. The mean (±SD) initial serum creatinine levels were 0.66 ± 0.08, 0.73 ± 0.05 and 0.74 ± 0.12 mg/dl, mean final serum creatinine level were 0.67 ± 0.07, 2.86 ± 0.07 and 1.60 ± 0.33 mg/dl, in group A1, group A2 and group B respectively. Conclusion: This study found that the gentamicin induced kidney damage was observed ............