DOI: https://doi.org/10.36347/sjams.2024.v12i08.027

Pages: 1086-1091

Background: Platelet-rich plasma (PRP) therapy holds promise as a treatment for androgenetic alopecia (AGA). This study aimed to compare the clinical efficacy of PRP therapy, minoxidil, and their combination in treating men with AGA, and to evaluate PRP's effects on hair follicle (HF) cell proliferation via skin biopsy. Materials and Methods: This prospective study was carried out at tertiary hospital from June 2021 to June 2022. A total of 69 men were divided into three groups: PRP therapy, minoxidil, and combined therapy. Clinical efficacy was assessed through hair morphometrics, while cell proliferation was evaluated using antibodies against β-catenin, CD34, Ki67, and Dkk-1. Results: PRP therapy proved more effective than minoxidil (p = 0.005). Combined therapy significantly outperformed minoxidil monotherapy (p < 0.0001) and PRP monotherapy (p = 0.007). Following PRP application, there was a notable increase in the absolute and relative expression areas of β-catenin and CD34, alongside a significant rise in the Ki67+ index. Conclusions: PRP represents a viable treatment option for AGA. Combining PRP with minoxidil shows promise in enhancing treatment outcomes for AGA by increasing HF cell proliferative activity and improving hair morphology.