DOI: https://doi.org/10.36347/sasjs.2024.v10i09.001

Pages: 999-1014

Gallbladder cancer (GBC) is the most common cancer of the biliary tract but the sixth most common cancer of the gastrointestinal tract. This tumor has a very high death rate. It is impossible to emphasize how crucial early diagnosis is because GBC grows subtly when it is discovered later. A number of environmental and genetic factors have been linked to the beginning of GBC. Environmental variables such as cholelithiasis, chronic inflammation of the biliary tract, and parasite infections are known to have a substantial impact on the development of gallbladder cancer. Congenital causes include abnormalities in the pancreaticobiliary duct junction and biliary cysts. Over the last ten years, advancements in imaging technology coupled with a more aggressive and drastic surgical approach have enhanced patient outcomes and contributed to longer survival times for GBC patients. This review article focuses on the epidemiology of GBC, its risk factors, and clinical characteristics.