DOI: 10.36347/sjams.2020.v08i10.026

Pages: 2352-2354

One of the major complication of hypothyroidism is atherosclerosis and cardio vascular disease. In worldwide, atherosclerosis is one of the leading cause of death and disability. Thyroid hormone increases LPL enzyme activity, LDL receptor gene expression, HMG CoA reductase activity and increases cholesterol excretion. In hypothyroidism hypercholesterolemia leads to production of reactive oxygen species that oxidises LDL which favours formation of atheromatous plaque which is responsible for foam cell formation [1]. Treatment with thyroxine decreases cholesterol level by upregulation of LDL receptors and increases its excretion through bile. This study group included 30 recently diagnosed hypothyroid individuals, 30 treated hypothyroid patients and 30 apparently healthy controls with age and sex matched. Thyroid profile and Lipid profile were measured in fasting blood samples. Total cholesterol, triglycerides and LDL-cholesterol were increased in recently diagnosed hypothyroidism compared to treated hypothyroidism and controls with the p value of <0.001. By this study we confirmed that altered lipid profile in hypothyroidism, one of the treatable cause for atherosclerosis. During treatment with thyroxine, hypothyroid patients should monitored for lipid profile, which may used as screening test to identify cardiovascular risk.