DOI: https://doi.org/10.36347/gamj.2024.v05i04.001

Pages: 104-109

Introduction: Among the different types of autoimmune encephalitis, anti-Dipeptidyl peptidase-like protein 6 (anti-DPPX) antibody encephalitis is characterized by its clinical polymorphism associating neuropsychiatric manifestations including cerebellar ataxia, agitation, confusion, abnormal movements (myoclonus, tremor), convulsion, dysautonomic syndrome and sleep disorder; urinary symptoms; dermatological symptoms and digestive symptoms; and the presence of a specific antibody called anti-Dipeptidyl peptidase-like protein 6 (anti-DPPX) antibody. We report, to our knowledge, the first Malian case report of probable anti-Dipeptidyl peptidase-like protein 6 (anti-DPPX) antibody encephalitis diagnosed in a young woman in Internal Medicine. Case Presentation: A 38-year-old Malian female, multiparous with no history of abortion, was hospitalized in internal medicine department at the University Hospital Center of the Point G in august 2024 with 2-years history of chronic intermittent diarrhea and abdominal pain of which the current episode accompanied with early postprandial vomiting started 2 weeks ago. Her medical and surgical histories included the gestational arterial hypertension and the caesarean section complicated by a postoperative wound infection and a lower limb thrombophlebitis in 2017. In 2021, the patient complained of chronic headache, dizziness, urgenturia and hypersudation evolving in the context of significant progressive weight loss, asthenia, anorexia and intermittent prolonged fever. In 2022, the neurological symptoms worsened with adjunction of plantar burning, tingling, prickling, sometime itching, walking and balance disorder leading intermittently the astasia-abasia, tremor of the extremities, and hypersomnia. Six months prior to admission, she presented with an achromic patch on the areola of the right breast, multiple scarring bullous lesions in the form of hypochromic patches, priritus, and hair loss. Then, three weeks before admission, .....