DOI: 10.36347/sjams.2020.v08i11.011

Pages: 2493-2496

Background: Septicemia in new born is of major public health concern, though recent medical advances have improved neonatal care, there are still many challenges remaining in the diagnosis and management of neonatal infection. Immature immune system and invasive life support make the premature neonates susceptible to infections. The diagnosis is complicated especially by the presence of noninfectious conditions. Objective: To study the Clinical and Bacteriological profile and antibiotic susceptibility pattern of septicemic neonates in the microbiology department, Niloufer hospital and find the significant risk factors leading to cause septicemia. Methods: Retrospective study was carried out in the Department of Microbiology at Niloufer Hospital, Red hills between January 2019 to Nov 2019.737 clinically suspected samples were included in the study, were processed. Identification and antibiogram of the isolates were done as per standard procedures. Clinical symptoms, Laboratory Parameters, Risk factors were statistical analysed, pvalue < 0.05 was considered significant. Results: Among 737 samples, 135 isolates identified and grouped.Gram positive organism 98 (72%) out of which Coagulase Negative Staphylococcus 93(68.9%). CoNS causing Proven Sepsis were 66 (48.9%). Among Gram Negative Organism Klebsiella pneumonia (48.6%) was commonest. Elevated CRP levels was significant to categorise CoNS isolate. Neutropenia and Thrombocytopeniawere significant in Gram negative sepsis. All the clinical symptoms and Risk factors were significant. Conclusion: Low birth weight and premature neonates are the greatest risk factors for the neonatal sepsis. Immature host defense mechanism and prolong use of CentralVenous catheters, mechanical ventilation, parenteral nutrition has led to the increase risk of CoNS infection in Late onset sepsis.By updating the Antibiotic policy can decrease the usage of Catheters and early shifting to enteral feeding can decrease the chance of late onset....