DOI: 10.36347/sjams.2020.v08i11.019

Pages: 2534-2540

Background: Billirubin is a yellowish substance in blood. It forms after red blood cells break down, and it travels through your blood. It forms after red blood cells break down, and it travels through your liver, gallbladder and digestive tract before being excreted. Typically, billirubin levels fall somewhere between 0.3 and 1.2 milligrams per deciliter (mg/dl). A billirubin test measures the amount of billirubin in your blood. It’s used to help find the cause of health condition like jaundice, anemia and liver disease. Bilirubin is an orange-yellow pigment that occurs normally when part of your red blood cells break down. The liver, however, is able to replace damaged tissue with new cells. If up to 50 to 60 percent of the liver cells may be killed within three to four days in an extreme case like Tylenol overdose, the liver will repair completely after 30 days if no complications arise. Child-Turcotte-Pugh (CTP), model for end stage liver disease (MELD) and MELD sodium (MELD-Na) scores are used for predicting disease severity and mortality among patients with end-stage liver disease. If MELD score is under 10: It will be recalculated once a year: 11-18: It will be recalculated every 3 months. 19-24: It will be recalculated once a month. 25 or higher: It will be recalculated every week. Aims: The goal to see the comparison of serum bilirubin, CTP and Meld score in patients with HBV-ACLF. Methodology: In this study a total of 32 acute on chronic Hepatitis B liver failure patients (age > 18 years with both sexes but male predominant) were included in Hepatology department of Bangabandhu Sheikh Mujib Medical University, Dhaka during January 2013 to December 2015. The patients were randomized into two groups: Tenofovir group (N=16) and Entecavir group (N=16) and followed at least for 03 months. Result: The total study population was 32 patients 16 (50.00%) males and 16 (50.00%) females. Table-1 demonstrted the characteristics of patients with serum bilirubin, .......