DOI: https://doi.org/10.36347/gamj.2024.v05i04.006

Pages: 136-140

Azadirachta Indica (Neem), a plant widely used in traditional medicine, has shown potential therapeutic effects in treating various oral conditions, particularly oral aphthae. Neem’s known properties include anti-inflammatory, antimicrobial, and wound-healing actions, which effectively promote healing and alleviate symptoms in oral ulcers. Previous studies have highlighted Neem’s significant antiulcer effects, with Nimbidin shown to prevent lesions induced by agents like acetylsalicylic acid and histamine [Liang et al., 2012]. According to Dr. K.M. Nadkarni in Indian Materia Medica (1954), heated Neem leaves or pastes are also effective antiseptics for skin diseases, ulcers, and pustules, and, when combined with Katuki and Chiretta, they treat fevers and soothe unhealthy ulcers [Nadkarni, 1954] These observations suggest Neem could be an effective treatment for unhealthy ulcerations. A sample of 30 patients with oral aphthous ulcers was taken to evaluate the antiulcer properties of Azadirachta Indica. The study used Neem mother tincture, with patients being monitored over two weeks. Changes in ulcer size, pain levels (measured using the Ulcer Severity Score, USS), and healing times were recorded, along with the occurrence of any adverse effects Patients treated with Azadirachta Indica (Neem) showed significant improvements. By the first week, there was a 40% reduction in ulcer size, which increased to 70% by the second week. Pain levels decreased by 50% in the first week and by 80% by the second week. The average pre-treatment USS score of 43.60 dropped to 28.67 post-treatment, indicating a 34.25% overall improvement. No significant adverse effects were reported, and the study demonstrated highly significant efficacy with a p-value of <0.001. This study demonstrates that Azadirachta Indica Ø is an effective treatment for oral aphthous ulcers. The reduction in ulcer size, pain, and recurrence rates, along with the absence of notable adverse effects, supports the use