DOI: https://doi.org/10.36347/sjams.2025.v13i01.020

Pages: 120-129

This study was aimed to evaluate different categories of urinary tract infection (UTI), causative organisms and their antibiotic sensitivity/resistance pattern with treatment response at a tertiary care hospital in Bangladesh. This study was conducted at the Department of Nephrology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh over a period of five years from January 2019 to December 2023. A total of 3000 patients with UTI were enrolled. Patients with complicated UTI, uncomplicated UTI and urosepsis were categorized. Their demographic profile, clinical characteristics of UTI, antibiotic sensitivity/resistant patterns, co-morbidity, obstructive features and treatment responses were recorded accordingly. Of them; 1365 (45.5%) were males and 1635 (54.5%) were females. The mean age of the study patients was 36.6 ± 16 years. Most of the UTI cases were presented with dysuria (46.7%) along with fever and chill (26.7%). Uncomplicated UTI was observed in 27% study cases and complicated UTI was in 11% cases, of these; upper UTI was 9% and lower was 29%. Normal renal function was observed in 57.3% study patients. Majority (83.3%) of the urine sample showed bacterial colony count >105 cfu/ml. Among gram-positive bacteria Staphylococcus. Enterococcus, group-B Streptococci were common. Among gram-negative bacteria E. Coli, Pseudomonas, Klebsiella and Proteus were identified. Diabetes is the leading cause of co-morbidity associated with UTI. Different obstructive features were observed among the study population. Antibiogram showed Colistin has highest degree of antibacterial sensitivity against E. Coli (around 80%). Staphylococcus Aureus was sensitive to Linezolid in 92% cases, Pseudomonas to imipenem in 85% cases. Klebsiella in 90% cases to tazobactum and pipercillin, Enterococci in 86% cases to Amoxicillin and Clavulanic Acid, Proteus in 70% cases to Meropenam, Staphylococcus Saprophyticus in 76% cases to Lenozolid, Group-B Streptococci in 80% ...