DOI: https://doi.org/10.36347/sjams.2025.v13i01.023

Pages: 142-147

Introduction: Thalassemia, a hereditary hemoglobinopathy, causes chronic hemolytic anemia and complications like hypogonadism due to iron overload and endocrine dysfunction. Despite advancements in transfusion and iron chelation therapies, gonadal dysfunction remains prevalent. This study aims to assess gonadal function in beta-thalassemia patients, exploring hormonal profiles, pubertal development, and menstrual irregularities to improve disease management and quality of life in affected individuals. Objectives: To assess gonadal function and its association with serum ferritin levels and transfusion frequency in beta-thalassemia patients. Method and Materials: This cross-sectional study included 150 beta-thalassemia patients attending the Haematology Outpatient Department at BSMMU from January to December 2022. Data were collected through clinical history, physical examinations, and laboratory tests, including hemoglobin, serum ferritin, hormonal profiles (LH, FSH, testosterone, estradiol), and Tanner staging. Statistical analysis was performed using SPSS Version 21.0. Ethical approval and informed consent were obtained before initiating the study. Results: Among 150 patients, the majority (35.3%) were aged 10–15 years, with 61.3% males and 34.7% students. Severe anemia (Hb ≤7 g/dL) was seen in 33.3%, and 28.7% required 6–10 blood transfusions annually. Ferritin levels of 2001–3000 ng/mL were most common (40%). Secondary hypogonadism was observed in 46%, and 27.3% were in Stage III Tanner puberty development. Conclusion: This study highlights severe anemia, frequent transfusion dependence, elevated ferritin levels, and significant gonadal dysfunction in beta-thalassemia patients.