DOI: https://doi.org/10.36347/sjmcr.2025.v13i01.024

Pages: 109-113

Psychosis is an amalgamation of psychological symptoms resulting in a loss of contact with reality. Approximately 1.5% to 3.5% of the general population will meet the diagnostic criteria for a psychotic disorder, and around 3 in 100 individuals will experience isolated psychotic symptoms in their lifetime. On the other hand, venous thromboembolism (VTE) is a chronic condition that affects nearly 10 million people every year worldwide. The relationship between psychiatric disorders and thrombotic events has garnered increasing attention in recent years, with emerging evidence suggesting a bidirectional association. We present the case of a 38-year-old female who developed psychotic symptoms in 2019, twelve years after being diagnosed with portal vein thrombosis (PVT). Despite undergoing two psychiatric consultations in 2019 and 2020, formal antipsychotic treatment was not initiated until 2024 when she was prescribed Aripiprazole and Lorazepam, resulting in moderate improvement. The temporal sequence and clinical manifestations suggest potential pathophysiological connections between vascular pathology and the development of a psychotic disorder, warranting further investigation into this relationship. This case contributes to the limited literature on this association and highlights the importance of comprehensive evaluation and management approaches in such cases.