DOI: https://doi.org/10.36347/sjmcr.2025.v13i01.029

Pages: 131-134

Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) syndrome is a rare and severe hypersensitivity reaction characterized by cutaneous, systemic, and biological involvement. Although uncommon, antitubercular drugs can induce this syndrome, posing significant management challenges. We report the case of a 70-year-old man treated for Pott's disease who developed DRESS syndrome during the continuation phase of antitubercular therapy. Symptoms included a widespread pruritic exanthem and severe eosinophilia (1,980/mm³). The diagnosis was confirmed by skin biopsy and the Registry of Severe Cutaneous Adverse Reaction (RegiSCAR) score. Withdrawal of suspected drugs and corticosteroid therapy led to resolution of symptoms. Sequential reintroduction of antitubercular drugs under close monitoring allowed successful completion of therapy without recurrence. This case highlights the importance of early recognition and meticulous management of DRESS syndrome in patients undergoing essential prolonged therapies.