DOI: https://doi.org/10.36347/sjmcr.2025.v13i01.040

Pages: 173-177

Introduction: Plasmablastic lymphoma is a subtype of diffuse large B-cell lymphoma. It is more frequent in immunosuppressed patients, with the oral cavity being the most common site of involvement, with less frequency in other extranodal regions such as paranasal sinuses, orbit, skin, bone and soft tissues. It is aggressive and has a poor prognosis, with an average survival of 1 year [1]. Clinical Case: We present he clinical case of a 69-year-old male patient, derived from neurosurgery due to a tumor in the frontal region of two weeks' evolution, nasal ventilatory insufficiency of the left nostril of 2 years' evolution, for 2 months he presented recurrent epistaxis. On physical examination a tumor in the frontal region was evident. CERS plus bicoronal craniectomy, resection of the rhinosinusal tumor was performed. Discussion: Plasmablastic lymphoma is a subtype of diffuse large B-cell lymphoma. It is more frequent in immunosuppressed patients, the oral cavity being the most common site of involvement, less frequently in other extranodal regions as in the case of the patient of rhinosinusal origin [5]. Conclusion: It is a diagnostic challenge, both its clinical and histological characteristics are ambiguous, which reduces the capacity for an accurate and rapid diagnosis, it requires intensive treatment with chemotherapy, however, it has a poor prognosis [7].