DOI: https://doi.org/10.36347/sajb.2025.v13i01.017

Pages: 164-176

This article explores the potential of phytochemicals as immunomodulatory agents in cancer therapy, bridging the gap between traditional plant-based medicine and modern oncological treatments. Phytochemicals, including flavonoids, alkaloids, terpenoids, and polyphenols, have demonstrated significant immunomodulatory properties that can enhance immune system function and promote anti-tumor responses. These bioactive compounds work by modulating key signaling pathways, including immune cell activation, cytokine production, and tumor microenvironment interactions. Despite their promising therapeutic potential, challenges remain in optimizing their bioavailability and therapeutic efficacy. This review highlights the latest advances in the use of phytochemicals for cancer immunotherapy, discussing their mechanisms of action, clinical applications, and the need for further research to fully harness their potential in combination with existing cancer treatments. Integrating these natural compounds into modern cancer therapy could provide novel, effective and less toxic treatment options for cancer patients.