DOI: 10.36347/sasjm.2020.v06i02.004

Pages: 38-46

Background: Non-Alcoholic fatty liver disease (NAFLD) has become a worldwide health concern with increase in the global incidence of obesity and it is now considered the hepatic component of the metabolic syndrome. As a result of epidemic increase in hypertension, obesity, hypertriglyceridemia along with diabetes mellitus, prevalence of NAFLD and metabolic syndrome have increased globally. Aims and Objective: The study’s aim was to compare the indices of the metabolic syndrome in compensated chronic liver disease patients with and without NAFLD at Rajshahi Medical College Hospital, Rajshahi, Bangladesh. Materials and Methods: A total of 91 consecutive patients with compensated chronic liver disease were recruited into the study. A structured questionnaire was administered to obtain relevant socio-demographic data. NAFLD was diagnosed based on clinical, biochemical, ultrasonographic and in a few histological features. The Adult Treatment Panel III criteria were used to identify patients with the metabolic syndrome. Results: Out of ninety one DM patients 2/3rd (67%) were male and remaining 1/3rd (33%) were female. Mean age of them was 51.43±6.24 years. Among study population 80.2% were obese, 31.8 were hypertensive and 72.5% had hypertriglyceridemia. Proportion of NAFLD and metabolic syndrome in T2DM patients was 60.4% and 61.5% respectively. 52.7% had mild whereas 47.3% had moderate fatty change in liver for persons without NAFLD. The difference was not statistically significant (p=0.2). In this study demographic variables like BMI, waist circumference were significantly associated with presence of fatty liver in T2DM patients (p=0.000 and p=0.000 respectively). HbA1c was significantly associated with presence of NAFLD (p=0.000) but ALT, AST and AST: ALT were not significantly associated with presence of NAFLD in T2DM patients (p=0.681, p=0.943 and p=0.749 respectively). Conclusion: Indices of the metabolic syndrome were more prevalent in persons with NAFLD..........