DOI: https://doi.org/10.36347/sjams.2025.v13i03.012

Pages: 676-681

Background: Cirrhosis is a chronic liver illness characterized by the loss and regeneration of hepatic parenchymal cells, as well as a broad increase in connective tissue, resulting in lobular architectural disarray. Cirrhosis of the liver is a major public health concern, causing significant morbidity and mortality worldwide. Aim of the study: The purpose of this study is to investigate the changed levels of HDL and LDL in patients with cirrhosis of the liver and their connection to severity. Methods: A hospital-based case control observational study was carried out in the Department of Gastrointestinal, Hepatobiliary, and Pancreatic Disorders (GHPD), BIRDEM in Dhaka, between January 2018 and September 2019. A total of 90 cirrhotic patients were chosen based on inclusion and exclusion criteria, with an age- and gender-matched control group of 90 healthy individuals. All data was collected, documented in a Microsoft Excel workbook, and analyzed with descriptive statistics in SPSS 23.0. Results: The most of cirrhotic patients were male (70%) where 30% were female. The mean age of cirrhotic patients was of 51.29±12.90 years and in control group mean age was 49.89±11.83 years. The mean value of HDL and LDL were 25.02±10.85 and 79.82±35.83 respectively. The mean (±SD) of HDL was 35.51±11.46 mg/dl in control group, 26.81±9.26 in Child-Pugh A group, 27.77±12.98 mg/dl in Child-Pugh B group and 19.30±7.71 mg/dl in Child-Pugh C group. The mean HDL between Child-Pugh A and Child-Pugh B patients was not statistically significant (p =0.736). The mean LDL between Child-Pugh A and Child-Pugh B patients was not statistically significant (p =0.197). The CP Score and HDL showed a strong negative connection (r=-0.287; p=0.006). There is a substantial negative association (r=-0.262; p=0.013) between the CP Score and LDL. Conclusion: Patients with liver cirrhosis frequently have hypolipidemia. According to our research, cirrhosis patients had lower lipid profile characteristics; ...