DOI: https://doi.org/10.36347/sjams.2025.v13i03.013

Pages: 682-687

Background: Chronic liver disease (CLD) is a significant global health burden, often progressing to cirrhosis. Early and accurate diagnosis of cirrhosis is critical for effective management and treatment. Liver stiffness measurement (LSM) is a non-invasive technique that has shown promise in diagnosing cirrhosis in CLD patients. Aim of the study: The present study aims to assess the accuracy of LSM for diagnosing cirrhosis in a diverse cohort of CLD patients. Methods: This observational study included 100 CLD patients diagnosed with varying etiologies of liver disease. LSM was performed to assess liver stiffness, and its diagnostic accuracy was evaluated using sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and overall accuracy. Comparisons were made between LSM and other diagnostic tools, including liver biopsy, imaging, and clinical assessments. Result: LSM demonstrated a sensitivity of 90%, specificity of 85%, and an accuracy of 87.5% for diagnosing cirrhosis, with optimal cutoff values of 10, 12.5, and 15 kPa. Multivariate analysis identified liver stiffness as a significant predictor of liver disease progression. Compared to the APRI and FIB-4 scores, LSM showed superior diagnostic performance across all metrics. Conclusion: LSM is a reliable and accurate non-invasive tool for diagnosing cirrhosis in CLD patients. It outperforms traditional biomarkers and clinical assessments, offering a promising alternative to liver biopsy. Further studies are warranted to validate its use in diverse populations and clinical settings.