DOI: https://doi.org/10.36347/sasjm.2025.v11i03.008

Pages: 164-171

Carcinoid heart disease (CHD) is a rare cardiac complication linked to advanced neuroendocrine tumors and carcinoid syndrome, predominantly affecting the right heart valves and potentially leading to right heart failure. The exact mechanisms behind CHD are not fully understood but are believed to involve various vasoactive substances released by the tumor. Managing CHD is complex because it requires addressing both the systemic malignancy and its cardiac effects. Early diagnosis and prompt surgical intervention are critical, as CHD is associated with increased morbidity and mortality. Valve replacement surgery can relieve right heart failure and may improve survival. We describe the case of a 58-year-old patient with a history of pancreatic neuroendocrine tumor and liver metastases, who was admitted with right-sided heart failure associated with carcinoid heart disease. This study provides a detailed review of the current literature on CHD, focusing primarily on its pathophysiology while also addressing clinical presentation, diagnostic approaches, and treatment options.