DOI: https://doi.org/10.36347/sjmcr.2025.v13i03.038

Pages: 490-493

There is a clear association between radiotherapy and an increased risk of developing secondary cancers, including sarcomas. Leiomyosarcoma is one of the rare secondary tumors reported after radiotherapy treatment. We report a rare case of laryngeal leiomyosarcoma in a 72-year-old patient with a history of radiotherapy for nasopharyngeal carcinoma treated seventeen years earlier. The patient mainly presented with progressively worsening dysphagia. The treatment consisted of surgical excision followed by adjuvant radiotherapy. The outcome was favorable. Through this case report, we aim to highlight this rare secondary tumor and its association with the effects of radiotherapy. We will also review the main therapeutic modalities for this entity.