DOI: https://doi.org/10.36347/sjmcr.2025.v13i03.039

Pages: 494-495

Introduction: Refractory hypocalcemia is a challenging condition that does not respond to standard treatment. One rare cause is malabsorption syndrome, which impairs the absorption of calcium and other nutrients. Patient and Methods: A 34-year-old female with secondary hypocalcemia and hypothyroidism presented with refractory hypocalcemia. Despite treatment, her calcium levels remained low. Investigations revealed malabsorption, including chronic gastritis with Helicobacter pylori infection and inflammatory bowel lesions. Discussion: Malabsorption syndromes impair calcium and magnesium absorption, leading to persistent hypocalcemia. Management includes treating the underlying condition and supplementing calcium, vitamin D, and magnesium. Conclusion: Refractory hypocalcemia due to malabsorption requires early recognition and a multidisciplinary approach, including addressing gastrointestinal issues and providing proper supplementation for effective management.