DOI: https://doi.org/10.36347/sjmcr.2025.v13i03.050

Pages: 534-537

Fibrous dysplasia of bone is a congenital but non-hereditary benign bone disorder in which normal bone is replaced by fibrous tissue containing immature osteogenesis. It is attributed to a mutation of the GNAS 1 gene on chromosome 20q13, an activating mutation of the subunit of the G protein. It is a disease that is most often silent, discovered accidentally on a standard X-ray or revealed by bone pain or a pathological fracture. Imaging and histology, when necessary, help to establish the diagnosis. Although it is not a tumor, it is often classified as a benign bone tumor for reasons of radiographic and anatomopathological differential diagnosis. It may be monostotic or polyostotic or part of McCune-Albright or Mazibraud syndromes. We report here a case of fibrous dysplasia to highlight the contribution of imaging in the positive and also differential diagnosis.