DOI: https://doi.org/10.36347/sajb.2025.v13i05.002

Pages: 500-508

The present study was carried out in the context of highlighting the nutritional and immunostimulant effect of a phytomedicine (LPRD33) on leukocyte parameters in Wistar strain rats. 16 rats aged twelve (12) weeks and weighing between 100-150g for males and females were used. These rats after being immunocompromised induced by cyclophosphamide (Endoxan, Bayër, France) were fed with increasing doses of (77, 154 and 308 mg/kg bw) of LPRD33. Effects of the different doses of LPRD33 were then evaluated. No visible signs or mortality were observed in the rats during the 14 days of experimentation based on the observation of clinical signs following the administration of the LPRD33 product. Results, however, showed that administration of LPRD33 at doses of 77, 154 and 308 mg/kg bw caused an increase in the number of disturbed white blood cells, lymphocytes, monocytes and neutrophils, which clearly shows the stimulating properties of LPRD33. Indeed, the 308 mg/kg bw dose of LPRD33 promoted a better rate of blood cell recovery. This study shows that LPRD33 contains bioactive substances (secondary metabolites) that can stimulate immune cells. Therefore, it could be used as a nutrient and immunostimulating agent for strengthening immune capacity and body well-being.