DOI: https://doi.org/10.36347/sjmcr.2025.v13i05.050

Pages: 971-973

Acute pancreatitis is an uncommon initial presentation of systemic lupus erythematosus (SLE). We describe the case of a 24-year-old woman hospitalized for acute epigastric pain suggestive of pancreatitis, along with fatigue and weight loss. After ruling out common causes and observing the development of pancytopenia and suggestive skin lesions, immunological testing led to the diagnosis of SLE. This case illustrates an unusual gastrointestinal onset of lupus and highlights the need for clinical vigilance in unexplained pancreatitis in young women.