DOI: https://doi.org/10.36347/sajp.2025.v14i04.003

Pages: 86-90

Myocardial infarction (MI), also referred to heart attacks, as are the leading cause of cardiovascular death in the majority of nations worldwide. MI is caused by blockage of one or more coronary arteries that supply blood to the heart. This deprives a portion of the heart of oxygenated blood and nutrients, which ultimately results in myocardial necrosis. Curcumin is a poly-phenolic chemical which is largely produced from turmeric rhizome (Curcuma longa). The health benefits of curcumin are well-documented; notably, curcumin demonstrates anticancer, antiviral, antioxidant, anti-inflammatory, antibacterial, hypoglycemic, and ant rheumatic activities. The heart's Histopathological findings demonstrated how Nano-curcumin and Nano-turmeric preserve cardiac tissue and help to avoid major complications. Histopathological analysis revealed that the group treated with nano-curcumin at a dose of 300 mg/kg b.w. demonstrated the most significant protective effect (P ≤ 0.05) compared to all other experimental groups. The cardiac tissue showed nearly normal myocardial architecture, with well-preserved and regularly arranged myofibers, minimal interstitial edema, absence of hemorrhage, and markedly reduced inflammatory cell infiltration, indicating effective attenuation of adrenaline-induced myocardial damage. The study shows the experimental parts endorsed conclusion that curcumin and turmeric may exhibit remarkable therapeutic effect in adrenaline induced myocardial infarction by improving a number of inflammatory markers linked with myocardial infarction.