DOI: https://doi.org/10.36347/sajb.2025.v13i05.014

Pages: 602-613

Interest in natural preservative systems has increased due to the need for clean-label and chemical-free food items, especially when it comes to dairy-based food matrices that are extremely vulnerable to microbial spoiling. The many natural preservation techniques used to improve the microbiological stability and prolong the shelf life of dairy products, such as milk, yoghurt, cheese, and fermented drinks, are examined in this study. The effectiveness, mechanism of action, and potential for synergy of important natural antimicrobials, including bacteriocins (e.g., nisin, pediocin), enzymes (e.g., lysozyme, lactoperoxidase), essential oils derived from plants, and microbial metabolites, are evaluated. The function of bioactive substances and hurdle technologies, including encapsulation and nanocarriers, in enhancing the stability and regulated release of natural preservatives is also covered in the review. It also discusses developments in biopreservation that use probiotic strains and protective cultures to prevent spoiling and harmful microbes. The processes by which these natural chemicals interfere with genetic expression, block enzymatic systems, or damage microbial cell membranes are highlighted. Additionally taken into account are customer acceptability, sensory effects, and regulatory viewpoints. This review offers a thorough grasp of how natural preservatives can be strategically used to guarantee microbiological safety, extend shelf life, and preserve the quality of dairy-based food products in a sustainable and health-conscious way by fusing scientific discoveries with technological advancements.