DOI: https://doi.org/10.36347/sajb.2025.v13i05.016

Pages: 632-640

The role of Lupinus Arboreus, popularly known as the Nigerian Chikadoma plant extract in cannabis-induced psychotic behaviors in Wistar Rats was investigated in this study. The study was carried out in stages, starting with the collecting and identification of plant material. 25 study animals were divided into five neurobehavioural groups (1, 2, 3, 4, 5). Both extract and chemicals were administered orally for a period of 42 days. To determine all particulate parameters under inquiry, the study used established procedures. Histological and tissue biochemical studies were performed on the hippocampus. Treatment of cannabis resulted to a significantly increased (p<0.05) anxiety and when compared with depression but significantly impaired (p<0.05) memory, locomotors and exploratory assessment in the study animals which were overturned by the extract. Similarly, the treatment of the extract with tetrahydroxyflavone reversed the harmful effects of cannabis on the hippocampal histology of the research animals, as a result, the efficacy of the leaf extract of Nigerian Chikadoma plant may be credited to its phyto-constituents.