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Scholars Journal of Medical Case Reports | Volume-13 | Issue-06
Unusual Morphology in Acute Myeloid Leukemia: The Cup-Like Variant – Case Report and Literature Review
O. Naouis, O. Lamridi, H. Yahyaoui, M. Chakour
Published: June 13, 2025 | 29 28
DOI: https://doi.org/10.36347/sjmcr.2025.v13i06.028
Pages: 1417-1419
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Abstract
Cup like acute myeloid leukemia (CL AML) is a rare form of acute myeloid leukemia, but its frequency is probably underestimated because it is a poorly understood and little described entity. Characterized by a particular biological profile: hyperleukocytosis, massive blastosis, disseminated intravenous coagulation, nuclei marked by a clear nuclear invagination, relatively stereotyped immunophenotype: CD34- / HLA-DR- / MPO + / CD117 + / CD13 +. Often associated with a normal karyotype, CL AML cytology is highly predictive of molecular abnormalities.