DOI: https://doi.org/10.36347/sjmcr.2025.v13i07.005

Pages: 1549-1551

Pemphigus is an intraepithelial autoimmune blistering dermatosis. It often begins as a mucosal-only phase, primarily affecting the oral mucosa. When skin involvement occurs, it is typically secondary and presents as flaccid blisters on otherwise healthy skin, quickly replaced by post-bullous erosions with an epidermal collar. Nikolsky’s sign is positive in perilesional skin. Diagnosis is based on histological examination showing intraepithelial blistering with acantholytic cells and the presence of antibodies on direct immunofluorescence. Treatment relies on low-dose systemic corticosteroids combined with immunosuppressive treatment for isolated oral involvement. Cases with cutaneous involvement require high-dose systemic corticosteroids.