DOI: https://doi.org/10.36347/sjmcr.2025.v13i07.030

Pages: 1640-1643

Introduction: Primary cutaneous follicle center lymphoma (PCFCL) is the most frequent subtype of cutaneous B-cell lymphomas, typically presenting as slow-growing nodules on the face or scalp. Dermoscopy and immunohistochemistry, particularly Bcl-2 expression, play an important role in diagnosis and prognosis. Case Presentation: We report a 51-year-old woman with a solitary, painless, erythematous nodule on the left cheek. Dermoscopy revealed a pink-salmon background, irregular linear vessels, rosettes, and chrysalis structures. Histology confirmed PCFCL with Bcl-2 positivity and a Ki-67 index of 30%. Staging ruled out systemic involvement. The lesion was excised, and the patient remains under follow-up. Discussion: This case highlights a classic clinical and dermoscopic presentation of PCFCL, emphasizing the role of dermoscopy in early suspicion. The expression of Bcl-2, present in approximately one-third of PCFCL cases, may be associated with an increased risk of cutaneous relapse, underlining the need for long-term dermatologic monitoring. Conclusion: In patients presenting with solitary facial nodules, PCFCL should be considered in the differential diagnosis. Dermoscopy offers useful orientation, and Bcl-2 expression may guide the intensity of follow-up. Early recognition and conservative skin-directed treatment ensure excellent outcomes.