DOI: https://doi.org/10.36347/sjmcr.2025.v13i07.032

Pages: 1649-1652

Staphylococcal toxidermia is a rare but potentially life-threatening condition in children, occasionally evolving toward a toxic epidermal necrolysis-like presentation (1). Case Presentation: We report the case of an 18-month-old female infant presenting with fever and impetiginous lesions rapidly evolving into a generalized exfoliative eruption suggestive of Lyell’s syndrome. Neurological deterioration was observed. Blood cultures were negative, but the clinical features were compatible with staphylococcal scalded skin syndrome (SSSS). The patient was treated with intravenous vancomycin and a 5-day course of immunoglobulins at 0.4 g/kg/day, resulting in a favorable outcome. Conclusion: This case highlights the importance of early recognition of severe staphylococcal skin syndromes and the potential benefit of adjunctive immunoglobulin therapy in extensive cases with neurological involvement.