DOI: https://doi.org/10.36347/sjmcr.2025.v13i07.042

Pages: 1687-1690

Cutaneous manifestations are frequently among the earliest clinical signs of systemic autoimmune diseases, often preceding or coinciding with internal organ involvement. As a readily accessible and observable organ, the skin serves as a valuable diagnostic window into systemic immune dysregulation. This review explores the most common and diagnostically relevant skin findings associated with systemic lupus erythematosus, dermatomyositis, systemic sclerosis, Sjögren’s syndrome, mixed connective tissue disease, vasculitides, and related disorders. Key dermatologic clues—including malar rash, Gottron’s papules, heliotrope rash, digital ulcers, Raynaud’s phenomenon, livedo reticularis, and purpura—are discussed in relation to their pathophysiology and systemic implications. By highlighting these cutaneous features, this article underscores the importance of early dermatologic recognition in the diagnosis, classification, and management of systemic autoimmune conditions. Greater awareness among clinicians of these skin signs can lead to earlier diagnosis, more targeted laboratory evaluation, and improved patient outcomes through timely interdisciplinary care.