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Scholars Journal of Medical Case Reports | Volume-13 | Issue-08
A Silent Hemoglobinopathy Revealed by Diffuse Osteosclerosis and Pseudo-Thrombotic Microangiopathy: Sickle Cell Disease
M. Zaizaa, F. Ahallat, M. Biat, I. El Kassimi, N. Bahadi, S. Nawal, J. Khalil, A. Tahiri, Z. El Bougrini, O. Jamal, B. Talamoussa, A. Rkiouak, Y. Sekkach
Published: Aug. 6, 2025 | 82 47
DOI: https://doi.org/10.36347/sjmcr.2025.v13i08.007
Pages: 1788-1791
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Abstract
We report the case of a 50-year-old female patient, with no family history of sickle cell disease, presenting with an anemic syndrome associated with back pain. Biological and morphological examinations revealed a pseudo-thrombotic microangiopathy and diffuse osteosclerotic osteopathy. The diagnosis of composite heterozygous sickle cell disease S/C was confirmed by hemoglobin electrophoresis. This case highlights an atypical clinical presentation of sickle cell disease, emphasizing the importance of a thorough differential diagnosis.