DOI: https://doi.org/10.36347/sajb.2025.v13i08.011

Pages: 1167-1176

Introduction: Istifragh, a fundamental concept in Unani medicine, refers to the evacuation of waste materials and morbid matter from the body to maintain health and prevent diseases. Rooted in ancient medical practices, istifragh encompasses various therapeutic methods such as hijamah (cupping), fasd (venesection), irsale-alaq (leeching), ishal (purgation) etc. Despite its historical significance and widespread use in Unani clinics, there is a pressing need to evaluate istifragh through modern clinical trials to validate its efficacy in contemporary medical practice. This paper aims to provide a comprehensive overview of istifragh while exploring its relevance in modern preventive and therapeutic strategies. Objectives: The primary objective of this research is to explore istifragh in the context of modern medicine, focusing on its physiological basis, therapeutic uses, and potential integration into healthcare. The study also emphasizes the importance of clinical trials to validate the effectiveness of istifragh. Methodology: This paper reviews classical Unani texts and contemporary literature to outline the principles and practices of istifragh. The physiological processes of food consumption, digestion, and waste elimination in Unani medicine are discussed, along with the pathophysiology of abnormal retention (ghayr taibai ihtibas) and its implications for disease development. The study also explores the concept of imala with or without istifragh. Key Findings: Istifragh is a vital therapeutic approach in Unani medicine, aimed at eliminating harmful substances and restoring the body’s natural balance. The principles of istifragh emphasize the importance of timely and moderate elimination, considering factors such as the patient’s temperament, strength, and the nature of the disease. Furthermore, the concept of imala (diversion of matter) is discussed as a complementary approach to istifragh, particularly in cases where complete elimination is not feasible. Conclu