DOI: https://doi.org/10.36347/sajb.2025.v13i08.022

Pages: 1283-1290

The medicinal recipe, composed of an aqueous extract of Parquetina nigrescens (Periplocaceae) and Erytrina senegalensis (Fabaceae) (RPNES) leaves, is used in traditional medicine in Ivory Coast to treat diabetes. This work aims to evaluate the antidiabetic potential of this drug recipe (RPNES) by studying its effects on the release of hepatic glucose in healthy rats and the storage of hepatic glucose in rats made diabetic by Streptozotocin. After 28 days of treatment of healthy rats with RPNES at doses of 400, 600 and 800 mg/kg BW, the dosage of glucose released by the liver, isolated and incubated at 37°C for 60 min in glucose-lactam Mac Ewen, shows that this recipe acts on liver function by reducing, in a dose-dependent manner, the release of hepatic glucose (glycogenolysis). In rats made diabetic by injection of streptozotocin, after 90 days of treatment with RPNES at a dose of 800 mg/kg BW, it appears that the drug formula promotes hepatic glucose storage (glycogenogenesis). The effects of RPNES at a dose of 800 mg/kg BW on hepatic glucose in rats are essentially identical to those obtained in rats treated with glibenclamide (10 mg/kg BW), the reference hypoglycemic and antidiabetic substance. This study also shows that in healthy rats, RPNES, administered for 28 days, does not cause changes in transaminase levels (ALAT and ASAT). Thus, it does not cause any damage to the liver of healthy rats. In rats made diabetic, then treated with RPNES for 28 days, the serum concentrations of these liver enzymes (ALAT and ASAT) decrease over time and return to normal. RPNES therefore corrects the liver damage caused by Streptozotocin. These results demonstrate that the medicinal formula composed of Parquetina nigrescens and Erytrina senegalensis has antidiabetic properties, justifying its use in traditional medicine for the treatment of diabetes.