DOI: https://doi.org/10.36347/sjmcr.2025.v13i08.046

Pages: 1940-1943

Keratoacanthoma is a rapidly growing skin tumor that often regresses spontaneously, but is frequently misdiagnosed as cutaneous squamous cell carcinoma, leading to underreporting and diagnostic challenges. It commonly affects men with sun-damaged skin, though rare variants like keratoacanthoma centrifugum marginatum may reach large sizes and resist spontaneous resolution. Diagnosis hinges on clinical presentation, triphasic growth pattern, and histopathological analysis. Treatment is typically advised due to potential for local destruction and diagnostic uncertainty. Standard excision is preferred for solitary lesions, while Mohs surgery, radiation therapy, and intralesional or topical chemotherapies are options for complex cases. Despite many therapeutic approaches, there are no universally accepted treatment guidelines, and recurrence rates vary from 1% to 8%.