DOI: https://doi.org/10.36347/sasjm.2025.v11i09.005

Pages: 853-859

Introduction: Chronic liver disease due to hepatitis B and C is common in our country, affecting over 10 million people. Globally, one in 12 people has hepatitis B or C. Thrombocytopenia, a frequent extrahepatic manifestation of CLD, can limit antiviral therapy by increasing bleeding risk. Aim of the study: The aim of this study was to assess the severity and clinical correlates of thrombocytopenia in chronic liver disease due to Hepatitis B and C. Methods: This cross-sectional observational study was conducted at Dhaka Medical College Hospital and Anwar Khan Modern Medical College from June to November 2011. In total 100 patients (79 patients of CHB and 21 patients of CHC) were enrolled on simple random sampling method from June 1 to 30 November 2011. All had full blood count with PBF, HBsAg /Anti-HCV by ELISA, abdominal ultrasound, upper GIT endoscopy and were assessed by Child-Pugh class. Thrombocytopenia was defined as platelet count below 150109/L. Result: The thrombocytopenia was 35.44% in CHB and 42.86% in CHC. In CHB, males were more affected, while in CHC both sexes were equally affected. Thrombocytopenia was more common in patients >40 years and occurred early in CHC but usually in late-stage CHB. Conclusion: Thrombocytopenia is a common and important findings in CLD due to HBV and HCV.