DOI: 10.36347/sajp.2012.v01i01.010

Pages: 56-60

Background: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a chronic inflammatory condition affecting the nasal and paranasal sinus mucosa, frequently associated with asthma as part of the “united airway disease” concept. This coexistence worsens patient quality of life and complicates management. Aim: To evaluate clinical profile, biochemical markers (blood eosinophil count, serum IgE), radiological grading, and treatment response in patients with CRSwNP and asthma. Methods: A prospective observational study was conducted on 50 patients diagnosed with CRSwNP and asthma. All participants underwent detailed clinical evaluation, laboratory investigations (CBC, eosinophil %, IgE), CT scan of paranasal sinuses (Lund–Mackay score), and standard treatment (medical ± surgical). Treatment outcome was assessed after 6 months. Results: The majority (62%) were between 30–50 years, with male-to-female ratio 1.2:1. Nasal obstruction (94%), rhinorrhea (80%), and hyposmia (72%) were the most common symptoms. Mean eosinophil count was 8.6 ± 2.1%, and mean IgE level was 365 ± 140 IU/mL, significantly above normal (p<0.001). Mean Lund–Mackay score was 15.3 ± 3.2. Combined medical and surgical management showed significant improvement in symptom scores (p<0.01) and asthma control. Conclusion: CRSwNP with asthma is strongly associated with eosinophilic inflammation and elevated IgE. Combined multidisciplinary management improves outcomes but recurrence remains a concern, highlighting the need for long-term follow-up and consideration of biologics in refractory cases.